High Error Rates in Selenocysteine Insertion in Mammalian Cells Treated with the Antibiotic Doxycycline, Chloramphenicol, or Geneticin

Antibiotics target bacteria by interfering with essential processes such as translation, but their effects on translation in mammalian cells are less well characterized. We found that doxycycline, chloramphenicol, and Geneticin (G418) interfered with insertion of selenocysteine (Sec), which is encod...

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Bibliographische Detailangaben
Hauptverfasser: Tobe, Ryuta, Naranjo-Suarez, Salvador, Everley, Robert A., Carlson, Bradley A., Turanov, Anton A., Tsuji, Petra A., Yoo, Min-Hyuk, Gygi, Steven P., Gladyshev, Vadim N., Hatfield, Dolph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663496/
https://ncbi.nlm.nih.gov/pubmed/23589299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446666
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