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Mitonuclear protein imbalance as a conserved longevity mechanism
Longevity is regulated by a network of intimately linked metabolic systems. We used a combination of mouse population genetics and RNAi in C. elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial ribosomal proteins (MRPs) as metabolic and longevity regulators. MRP kn...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3663447/ https://ncbi.nlm.nih.gov/pubmed/23698443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12188 |
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