Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-On/Tet-Off systems. The wide range of direct effects of tetracycline use has, however, not been fully appreciated. We show here that these antibiotics induce a mitonuclear pr...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Moullan, Norman, Mouchiroud, Laurent, Wang, Xu, Ryu, Dongryeol, Williams, Evan G., Mottis, Adrienne, Jovaisaite, Virginija, Frochaux, Michael V., Quiros, Pedro M., Deplancke, Bart, Houtkooper, Riekelt H., Auwerx, Johan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565776/
https://ncbi.nlm.nih.gov/pubmed/25772356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.034
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