Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-On/Tet-Off systems. The wide range of direct effects of tetracycline use has, however, not been fully appreciated. We show here that these antibiotics induce a mitonuclear pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Moullan, Norman, Mouchiroud, Laurent, Wang, Xu, Ryu, Dongryeol, Williams, Evan G., Mottis, Adrienne, Jovaisaite, Virginija, Frochaux, Michael V., Quiros, Pedro M., Deplancke, Bart, Houtkooper, Riekelt H., Auwerx, Johan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565776/
https://ncbi.nlm.nih.gov/pubmed/25772356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.034
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