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A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has proven challenging. It requires the measurement...

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Detalhes bibliográficos
Main Authors: Andreux, Pénélope A., Mouchiroud, Laurent, Wang, Xu, Jovaisaite, Virginija, Mottis, Adrienne, Bichet, Sabrina, Moullan, Norman, Houtkooper, Riekelt H., Auwerx, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055904/
https://ncbi.nlm.nih.gov/pubmed/24923838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05285
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