Mitonuclear protein imbalance as a conserved longevity mechanism

Longevity is regulated by a network of intimately linked metabolic systems. We used a combination of mouse population genetics and RNAi in C. elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial ribosomal proteins (MRPs) as metabolic and longevity regulators. MRP kn...

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Bibliographic Details
Main Authors: Houtkooper, Riekelt H., Mouchiroud, Laurent, Ryu, Dongryeol, Moullan, Norman, Katsyuba, Elena, Knott, Graham, Williams, Robert W., Auwerx, Johan
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663447/
https://ncbi.nlm.nih.gov/pubmed/23698443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12188
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