PARP1 is required for chromosomal translocations

Chromosomal translocations are common contributors to malignancy, yet little is known about the precise molecular mechanisms by which they are generated. Sequencing translocation junctions in acute leukemias revealed that the translocations were likely mediated by a DNA double-strand break repair pa...

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Detalhes bibliográficos
Main Authors: Wray, Justin, Williamson, Elizabeth A., Singh, Sudha B., Wu, Yuehan, Cogle, Christopher R., Weinstock, David M., Zhang, Yu, Lee, Suk-Hee, Zhou, Daohong, Shao, Lijian, Hauer-Jensen, Martin, Pathak, Rupak, Klimek, Virginia, Nickoloff, Jac A., Hromas, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663429/
https://ncbi.nlm.nih.gov/pubmed/23568489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-460527
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