PARP1 is required for chromosomal translocations

Chromosomal translocations are common contributors to malignancy, yet little is known about the precise molecular mechanisms by which they are generated. Sequencing translocation junctions in acute leukemias revealed that the translocations were likely mediated by a DNA double-strand break repair pa...

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Bibliographische Detailangaben
Hauptverfasser: Wray, Justin, Williamson, Elizabeth A., Singh, Sudha B., Wu, Yuehan, Cogle, Christopher R., Weinstock, David M., Zhang, Yu, Lee, Suk-Hee, Zhou, Daohong, Shao, Lijian, Hauer-Jensen, Martin, Pathak, Rupak, Klimek, Virginia, Nickoloff, Jac A., Hromas, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663429/
https://ncbi.nlm.nih.gov/pubmed/23568489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-460527
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