Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice

BACKGROUND: Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, the appropriate magnitude and timing of interventions are largely unknown, in...

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Autori principali: Majmudar, Maulik D., Keliher, Edmund J., Heidt, Timo, Leuschner, Florian, Truelove, Jessica, Sena, Brena F., Gorbatov, Rostic, Iwamoto, Yoshiko, Dutta, Partha, Wojtkiewicz, Gregory, Courties, Gabriel, Sebas, Matt, Borodovsky, Anna, Fitzgerald, Kevin, Nolte, Marc W., Dickneite, Gerhard, Chen, John W., Anderson, Daniel G., Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661714/
https://ncbi.nlm.nih.gov/pubmed/23616627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.000116
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