Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice

BACKGROUND: Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, the appropriate magnitude and timing of interventions are largely unknown, in...

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Detalhes bibliográficos
Main Authors: Majmudar, Maulik D., Keliher, Edmund J., Heidt, Timo, Leuschner, Florian, Truelove, Jessica, Sena, Brena F., Gorbatov, Rostic, Iwamoto, Yoshiko, Dutta, Partha, Wojtkiewicz, Gregory, Courties, Gabriel, Sebas, Matt, Borodovsky, Anna, Fitzgerald, Kevin, Nolte, Marc W., Dickneite, Gerhard, Chen, John W., Anderson, Daniel G., Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661714/
https://ncbi.nlm.nih.gov/pubmed/23616627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.000116
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