Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts

BACKGROUND: Macrophages (MΦ) predominate among the inflammatory cells in rejecting allografts. These innate immune cells, in addition to allospecific T cells, can damage cardiomyocytes directly. METHODS AND RESULTS: We explored if sensitive PET/CT imaging of MΦ-avid nanoparticles detects rejection o...

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Main Authors: Ueno, Takuya, Dutta, Partha, Keliher, Edmund, Leuschner, Florian, Majmudar, Maulik, Marinelli, Brett, Iwamoto, Yoshiko, Figueiredo, Jose-Luiz, Christen, Thomas, Swirski, Filip K., Libby, Peter, Weissleder, Ralph, Nahrendorf, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734553/
https://ncbi.nlm.nih.gov/pubmed/23771986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCIMAGING.113.000481
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