Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques

RATIONALE: Myeloid cell content in atherosclerotic plaques associates with rupture and thrombosis. Thus, imaging of lesional monocyte and macrophages (Mo/Mϕ) could serve as a biomarker of disease progression and therapeutic intervention. OBJECTIVE: To noninvasively assess plaque inflammation with de...

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Hauptverfasser: Majmudar, Maulik D., Yoo, Jeongsoo, Keliher, Edmund J., Truelove, Jessica, Iwamoto, Yoshiko, Sena, Brena, Dutta, Partha, Borodovsky, Anna, Fitzgerald, Kevin, Di Carli, Marcelo, Libby, Peter, Anderson, Daniel G., Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586287/
https://ncbi.nlm.nih.gov/pubmed/23300273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300576
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