E-selectin inhibition mitigates splenic HSC activation and myelopoiesis in hypercholesterolemic mice with myocardial infarction

OBJECTIVE: Atherosclerosis is a chronic disease characterized by lipid accumulation in the arterial wall. After MI, atherosclerotic plaques are infiltrated by inflammatory myeloid cells that aggravate the disease and increase the risk of secondary myocardial ischemia. Splenic myelopoiesis provides a...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Dutta, Partha, Hoyer, Friedrich Felix, Sun, Yuan, Iwamoto, Yoshiko, Tricot, Benoit, Weissleder, Ralph, Magnani, John L., Swirski, Filip K., Nahrendorf, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001901/
https://ncbi.nlm.nih.gov/pubmed/27470513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307519
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