In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing

OBJECTIVES: The aim of the study was to test wether silencing of the transcription factor Interferon Regulatory Factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post-MI remodeling. BACKGROUND: In healing wounds, M1➛M2 macrophage phenotype transition supports resolution...

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Hauptverfasser: Courties, Gabriel, Heidt, Timo, Sebas, Matthew, Iwamoto, Yoshiko, Jeon, Derrick, Truelove, Jessica, Tricot, Benoit, Wojtkiewicz, Greg, Dutta, Partha, Sager, Hendrik B., Borodovsky, Anna, Novobrantseva, Tatiana, Klebanov, Boris, Fitzgerald, Kevin, Anderson, Daniel G, Libby, Peter, Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992176/
https://ncbi.nlm.nih.gov/pubmed/24361318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2013.11.023
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