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Therapeutic Development in Targeting Protein-Protein Interactions With Synthetic Topological Mimetics
Protein-protein interactions lie at the heart of cellular signaling pathways and the deregulation of which has frequently led to diseases. In contrast to inhibitors that bind to distinctive enzyme active sites, molecules targeting protein surface topologies have been underexploited in drug developme...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660839/ https://ncbi.nlm.nih.gov/pubmed/22578832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2012.04.004 |
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