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Therapeutic Development in Targeting Protein-Protein Interactions With Synthetic Topological Mimetics
Protein-protein interactions lie at the heart of cellular signaling pathways and the deregulation of which has frequently led to diseases. In contrast to inhibitors that bind to distinctive enzyme active sites, molecules targeting protein surface topologies have been underexploited in drug developme...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660839/ https://ncbi.nlm.nih.gov/pubmed/22578832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2012.04.004 |
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