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Heterocyclic α-helix mimetics for targeting protein-protein interactions
The design and synthesis of α-helix peptidomimetics using inverse electron demand Diels-Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-X(L) interaction was tested using an in vitro Fluorescence Polarization Assay.
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2699934/ https://ncbi.nlm.nih.gov/pubmed/17555961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.05.075 |
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