T cell-specific Notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4(+) and CD8(+) T cells

Graft-versus-host disease (GVHD) induced by donor-derived T cells remains the major limitation of allogeneic bone marrow transplantation (allo-BMT). We previously reported that the pan-Notch inhibitor DNMAML markedly decreased the severity and mortality of acute GVHD mediated by CD4(+) T cells in mi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sandy, Ashley R., Chung, Jooho, Toubai, Tomomi, Shan, Gloria T., Tran, Ivy T., Friedman, Ann, Blackwell, Timothy S., Reddy, Pavan, King, Philip D., Maillard, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660433/
https://ncbi.nlm.nih.gov/pubmed/23636056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203452
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados