Notch signaling is a critical regulator of allogeneic CD4(+) T-cell responses mediating graft-versus-host disease

Graft-versus-host disease (GVHD) remains the major barrier to the success of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is caused by donor T cells that mediate host tissue injury through multiple inflammatory mechanisms. Blockade of individual effector molecules has limited effi...

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Bibliographic Details
Main Authors: Zhang, Yi, Sandy, Ashley R., Wang, Jina, Radojcic, Vedran, Shan, Gloria T., Tran, Ivy T., Friedman, Ann, Kato, Koji, He, Shan, Cui, Shuaiying, Hexner, Elizabeth, Frank, Dale M., Emerson, Stephen G., Pear, Warren S., Maillard, Ivan
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037751/
https://ncbi.nlm.nih.gov/pubmed/20870902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-271940
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