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Notch signaling is a critical regulator of allogeneic CD4(+) T-cell responses mediating graft-versus-host disease
Graft-versus-host disease (GVHD) remains the major barrier to the success of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is caused by donor T cells that mediate host tissue injury through multiple inflammatory mechanisms. Blockade of individual effector molecules has limited effi...
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Main Authors: | , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society of Hematology
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037751/ https://ncbi.nlm.nih.gov/pubmed/20870902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-271940 |
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