Human monoclonal ScFv that bind to different functional domains of M2 and inhibit H5N1 influenza virus replication

BACKGROUND: Novel effective anti-influenza agent that tolerates influenza virus antigenic variation is needed. Highly conserved influenza virus M2 protein has multiple pivotal functions including ion channel activity for vRNP uncoating, anti-autophagy and virus assembly, morphogenesis and release. T...

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Hlavní autoři: Pissawong, Tippawan, Maneewatch, Santi, Thueng-in, Kanyarat, Srimanote, Potjanee, Dong-din-on, Fonthip, Thanongsaksrikul, Jeeraphong, Songserm, Thaweesak, Tongtawe, Pongsri, Bangphoomi, Kunan, Chaicumpa, Wanpen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660209/
https://ncbi.nlm.nih.gov/pubmed/23672256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-148
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