Cell Penetrable Humanized-VH/V(H)H That Inhibit RNA Dependent RNA Polymerase (NS5B) of HCV

NS5B is pivotal RNA dependent RNA polymerase (RdRp) of HCV and NS5B function interfering halts the virus infective cycle. This work aimed to produce cell penetrable humanized single domain antibodies (SdAb; VH/V(H)H) that interfere with the RdRp activity. Recombinant NS5BΔ55 of genotype 3a HCV with...

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Detalhes bibliográficos
Main Authors: Thueng-in, Kanyarat, Thanongsaksrikul, Jeeraphong, Srimanote, Potjanee, Bangphoomi, Kunan, Poungpair, Ornnuthchar, Maneewatch, Santi, Choowongkomon, Kiattawee, Chaicumpa, Wanpen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493538/
https://ncbi.nlm.nih.gov/pubmed/23145135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049254
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