Human Transbodies to HCV NS3/4A Protease Inhibit Viral Replication and Restore Host Innate Immunity

A safe and effective direct acting anti-hepatitis C virus (HCV) agent is still needed. In this study, human single chain variable fragments of antibody (scFvs) that bound to HCV NS3/4A protein were produced by phage display technology. The engineered scFvs were linked to nonaarginines (R9) for makin...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jittavisutthikul, Surasak, Seesuay, Watee, Thanongsaksrikul, Jeeraphong, Thueng-in, Kanyarat, Srimanote, Potjanee, Werner, Rolf G., Chaicumpa, Wanpen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999588/
https://ncbi.nlm.nih.gov/pubmed/27617013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00318
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