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Humanized-Single Domain Antibodies (VH/V(H)H) that Bound Specifically to Naja kaouthia Phospholipase A2 and Neutralized the Enzymatic Activity

Naja kaouthia (monocled cobra) venom contains many isoforms of secreted phospholipase A2 (sPLA(2)). The PLA(2) exerts several pharmacologic and toxic effects in the snake bitten subject, dependent or independent on the enzymatic activity. N. kaouthia venom appeared in two protein profiles, P3 and P5...

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Hlavní autoři: Chavanayarn, Charnwit, Thanongsaksrikul, Jeeraphong, Thueng-in, Kanyarat, Bangphoomi, Kunan, Sookrung, Nitat, Chaicumpa, Wanpen
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407892/
https://ncbi.nlm.nih.gov/pubmed/22852068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins4070554
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