A V(H)H That Neutralizes the Zinc Metalloproteinase Activity of Botulinum Neurotoxin Type A

The current treatment of botulism is to administer animal-derived antitoxin, which frequently causes severe adverse reactions in the recipients. In this study, a heavy chain antibody fragment (VH/V(H)H) phage display library was constructed by amplification of the immunoglobulin genes of a nonimmune...

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Bibliographische Detailangaben
Hauptverfasser: Thanongsaksrikul, Jeeraphong, Srimanote, Potjanee, Maneewatch, Santi, Choowongkomon, Kiattawee, Tapchaisri, Pramuan, Makino, Sou-ichi, Kurazono, Hisao, Chaicumpa, Wanpen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843216/
https://ncbi.nlm.nih.gov/pubmed/20093370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073163
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