FTO-Mediated Formation of N(6)-Hydroxymethyladenosine and N(6)-Formyladenosine in Mammalian RNA

N(6)-methyladenosine (m(6)A) is a prevalent internal modification in mRNA and non- coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N(6)-hydroxymethyladenosine (hm(6)A) and N(6)- formyladenosine (f(6)A), in mammalian mRNA. We show that Fe(...

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Detalhes bibliográficos
Main Authors: Fu, Ye, Jia, Guifang, Pang, Xueqin, Wang, Richard N., Wang, Xiao, Li, Charles J., Smemo, Scott, Dai, Qing, Bailey, Kathleen A., Nobrega, Marcelo A., Han, Ke-li, Cui, Qiang, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658177/
https://ncbi.nlm.nih.gov/pubmed/23653210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2822
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