FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-methyladenosine (m(6)A) in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m(6)A levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Zhao, Xu, Yang, Ying, Sun, Bao-Fa, Shi, Yue, Yang, Xin, Xiao, Wen, Hao, Ya-Juan, Ping, Xiao-Li, Chen, Yu-Sheng, Wang, Wen-Jia, Jin, Kang-Xuan, Wang, Xing, Huang, Chun-Min, Fu, Yu, Ge, Xiao-Meng, Song, Shu-Hui, Jeong, Hyun Seok, Yanagisawa, Hiroyuki, Niu, Yamei, Jia, Gui-Fang, Wu, Wei, Tong, Wei-Min, Okamoto, Akimitsu, He, Chuan, Danielsen, Jannie M Rendtlew, Wang, Xiu-Jie, Yang, Yun-Gui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260349/
https://ncbi.nlm.nih.gov/pubmed/25412662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.151
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados