N(6)-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

We report here that FTO (fat mass and obesity-associated protein) exhibits efficient oxidative demethylation activity of abundant N(6)-methyladenosine (m(6)A) residues in RNA in vitro. FTO knockdown with siRNA led to an increased level of m(6)A in mRNA, whereas overexpression of FTO resulted in a de...

Full description

Saved in:
Bibliographic Details
Main Authors: Jia, Guifang, Fu, Ye, Zhao, Xu, Dai, Qing, Zheng, Guanqun, Yang, Ying, Yi, Chengqi, Lindahl, Tomas, Pan, Tao, Yang, Yun-Gui, He, Chuan
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218240/
https://ncbi.nlm.nih.gov/pubmed/22002720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.687
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items