N(6)-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO

We report here that FTO (fat mass and obesity-associated protein) exhibits efficient oxidative demethylation activity of abundant N(6)-methyladenosine (m(6)A) residues in RNA in vitro. FTO knockdown with siRNA led to an increased level of m(6)A in mRNA, whereas overexpression of FTO resulted in a de...

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Detalhes bibliográficos
Main Authors: Jia, Guifang, Fu, Ye, Zhao, Xu, Dai, Qing, Zheng, Guanqun, Yang, Ying, Yi, Chengqi, Lindahl, Tomas, Pan, Tao, Yang, Yun-Gui, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218240/
https://ncbi.nlm.nih.gov/pubmed/22002720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.687
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