A METTL3-METTL14 complex mediates mammalian nuclear RNA N(6)-adenosine methylation

N(6)-methyladenosine (m(6)A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m(6)A RNA methylation. Together with METTL3, the only previously known m(6)A methyltransferase, these two proteins form a st...

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Detalhes bibliográficos
Main Authors: Liu, Jianzhao, Yue, Yanan, Han, Dali, Wang, Xiao, Fu, Ye, Zhang, Liang, Jia, Guifang, Yu, Miao, Lu, Zhike, Deng, Xin, Dai, Qing, Chen, Weizhong, He, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911877/
https://ncbi.nlm.nih.gov/pubmed/24316715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1432
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