Evidence that ribonucleotides are signals for mismatch repair of leading strand replication errors

To maintain genome stability, mismatch repair of nuclear DNA replication errors must be directed to the nascent strand, likely by DNA ends and PCNA. Here we show that the efficiency of mismatch repair in Saccharomyces cerevisiae is reduced by inactivating RNase H2, which nicks DNA containing ribonuc...

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Bibliografiske detaljer
Main Authors: Lujan, Scott A., Williams, Jessica S., Clausen, Anders R., Clark, Alan B., Kunkel, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658170/
https://ncbi.nlm.nih.gov/pubmed/23603118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.017
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