Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform lagging strand replication. The fact that these po...

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Detalhes bibliográficos
Main Authors: Lujan, Scott A., Williams, Jessica S., Pursell, Zachary F., Abdulovic-Cui, Amy A., Clark, Alan B., Nick McElhinny, Stephanie A., Kunkel, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469411/
https://ncbi.nlm.nih.gov/pubmed/23071460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003016
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