Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the primary leading strand replicase, whereas Pols α and δ primarily perform lagging strand replication. The fact that these po...

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Main Authors: Lujan, Scott A., Williams, Jessica S., Pursell, Zachary F., Abdulovic-Cui, Amy A., Clark, Alan B., Nick McElhinny, Stephanie A., Kunkel, Thomas A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469411/
https://ncbi.nlm.nih.gov/pubmed/23071460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003016
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