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Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab
Prodrugs of dynemicin analogs were synthesized, and their activation by aldolase antibody (Ab) 38C2 was evaluated by DNA-cleaving activity, as well as tumor cell growth inhibition. Further, we provide evidence that the activated enediynes underwent covalent crosscoupling with the aldolase Ab, which...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC365749/ https://ncbi.nlm.nih.gov/pubmed/14981258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307319101 |
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