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Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach
A tricyclic precursor for the synthesis of the prodrugs of pro-1,2,9,9a-tetrahydrocyclopropa[c]benz-[e]indole-4-one tetramethoxyindolecarboxamide (CBI-TMI) was prepared using the ring-closing metathesis approach. The tricyclic intermediate was converted to an advanced precursor of a CBI-TMI prodrug...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768327/ https://ncbi.nlm.nih.gov/pubmed/20160897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.03.205 |
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