Imprint of evolution on protein structures

We attempt to understand the evolutionary origin of protein folds by simulating their divergent evolution with a three-dimensional lattice model. Starting from an initial seed lattice structure, evolution of model proteins progresses by sequence duplication and subsequent point mutations. A new gene...

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-д хэвлэсэн:	Proc Natl Acad Sci U S A
Үндсэн зохиолчид:	Tiana, Guido, Shakhnovich, Boris E., Dokholyan, Nikolay V., Shakhnovich, Eugene I.
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	National Academy of Sciences 2004
Нөхцлүүд:	Biological Sciences
Онлайн хандалт:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14970345/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0306638101
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