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Imprint of evolution on protein structures

We attempt to understand the evolutionary origin of protein folds by simulating their divergent evolution with a three-dimensional lattice model. Starting from an initial seed lattice structure, evolution of model proteins progresses by sequence duplication and subsequent point mutations. A new gene...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Proc Natl Acad Sci U S A
Ngā kaituhi matua: Tiana, Guido, Shakhnovich, Boris E., Dokholyan, Nikolay V., Shakhnovich, Eugene I.
Hōputu: Artigo
Reo:Inglês
I whakaputaina: National Academy of Sciences 2004
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365708/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14970345/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0306638101
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