Using protein design for homology detection and active site searches
We describe a method of designing artificial sequences that resemble naturally occurring sequences in terms of their compatibility with a template structure and its functional constraints. The design procedure is a Monte Carlo simulation of amino acid substitution process. The selective fixation of...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12975528/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2034878100 |
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