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Using protein design for homology detection and active site searches
We describe a method of designing artificial sequences that resemble naturally occurring sequences in terms of their compatibility with a template structure and its functional constraints. The design procedure is a Monte Carlo simulation of amino acid substitution process. The selective fixation of...
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| Main Authors: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2003
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC208762/ https://ncbi.nlm.nih.gov/pubmed/12975528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2034878100 |
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