Using protein design for homology detection and active site searches

We describe a method of designing artificial sequences that resemble naturally occurring sequences in terms of their compatibility with a template structure and its functional constraints. The design procedure is a Monte Carlo simulation of amino acid substitution process. The selective fixation of...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Pei, Jimin, Dokholyan, Nikolay V., Shakhnovich, Eugene I., Grishin, Nick V.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2003
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12975528/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2034878100
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