The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.

We have previously cloned and characterized two different dihydrofolate reductase amplicon types from a methotrexate-resistant Chinese hamster ovary cell line (CHOC 400). The largest of these (the type I amplicon) is 273 kilobases (kb) in length. In the present study, we utilized clones from the typ...

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Bibliographische Detailangaben
Hauptverfasser: Looney, J E, Ma, C, Leu, T H, Flintoff, W F, Troutman, W B, Hamlin, J L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1988
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC365629/
https://ncbi.nlm.nih.gov/pubmed/3244355
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