The dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.

We have previously cloned and characterized two different dihydrofolate reductase amplicon types from a methotrexate-resistant Chinese hamster ovary cell line (CHOC 400). The largest of these (the type I amplicon) is 273 kilobases (kb) in length. In the present study, we utilized clones from the typ...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Looney, J E, Ma, C, Leu, T H, Flintoff, W F, Troutman, W B, Hamlin, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3244355/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.12.5268-5279.1988
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