Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

The retinoic acid receptor (RAR) α system plays a key role in the adult brain, participating in the homeostatic control of synaptic plasticity, essential for memory function. Here we show that RARα signalling is down-regulated by amyloid beta (Aβ), which inhibits the synthesis of the endogenous liga...

Full description

Saved in:
Bibliographic Details
Main Authors: Goncalves, Maria B, Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P T
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Disorders of the Nervous System
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655538/
https://ncbi.nlm.nih.gov/pubmed/23379615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.12142
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items