Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

Por Goncalves, Maria B, Clarke, Earl, Hobbs, Carl, Malmqvist, Tony, Deacon, Robert, Jack, Julian, Corcoran, Jonathan P T
Publicado em 2013

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

Por Goncalves, Maria B., Wu, Yue, Trigo, Diogo, Clarke, Earl, Malmqvist, Tony, Grist, John, Hobbs, Carl, Carlstedt, Thomas P., Corcoran, Jonathan P.T.
Publicado no Neurobiol Dis (2018)

Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

Por Goncalves, Maria B., Malmqvist, Tony, Clarke, Earl, Hubens, Chantal J., Grist, John, Hobbs, Carl, Trigo, Diogo, Risling, Mårten, Angeria, Maria, Damberg, Peter, Carlstedt, Thomas P., Corcoran, Jonathan P.T
Publicado no J Neurosci (2015)

Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist

Por Clarke, Earl, Jarvis, Christopher I., Goncalves, Maria B., Kalindjian, S. Barret, Adams, David R., Brown, Jane T., Shiers, Jason J., Taddei, David M.A., Ravier, Elodie, Barlow, Stephanie, Miller, Iain, Smith, Vanessa, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publicado no Bioorg Med Chem (2018)