Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

Failure of axonal regeneration in the central nervous system (CNS) is mainly attributed to a lack of intrinsic neuronal growth programs and an inhibitory environment from a glial scar. Phosphatase and tensin homolog (PTEN) is a major negative regulator of neuronal regeneration and, as such, inhibiti...

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Udgivet i:J Neurosci
Main Authors: Goncalves, Maria B., Malmqvist, Tony, Clarke, Earl, Hubens, Chantal J., Grist, John, Hobbs, Carl, Trigo, Diogo, Risling, Mårten, Angeria, Maria, Damberg, Peter, Carlstedt, Thomas P., Corcoran, Jonathan P.T
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659830/
https://ncbi.nlm.nih.gov/pubmed/26609164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1339-15.2015
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