RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms

Neuropathic pain (NP) is associated with profound gene expression alterations within the nociceptive system. DNA mechanisms, such as epigenetic remodeling and repair pathways have been implicated in NP. Here we have used a rat model of peripheral nerve injury to study the effect of a recently develo...

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Publicado en:iScience
Autores principales: Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833472/
https://ncbi.nlm.nih.gov/pubmed/31655065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.020
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