RARβ Agonist Drug (C286) Demonstrates Efficacy in a Pre-clinical Neuropathic Pain Model Restoring Multiple Pathways via DNA Repair Mechanisms

Neuropathic pain (NP) is associated with profound gene expression alterations within the nociceptive system. DNA mechanisms, such as epigenetic remodeling and repair pathways have been implicated in NP. Here we have used a rat model of peripheral nerve injury to study the effect of a recently develo...

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Bibliographic Details
Published in:iScience
Main Authors: Goncalves, Maria B., Moehlin, Julien, Clarke, Earl, Grist, John, Hobbs, Carl, Carr, Antony M., Jack, Julian, Mendoza-Parra, Marco Antonio, Corcoran, Jonathan P.T.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833472/
https://ncbi.nlm.nih.gov/pubmed/31655065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.020
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