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Sleep-wake cycle and diurnal fluctuation of amyloid-β as biomarkers of brain amyloid pathology
Aggregation of amyloid-β (Aβ) in the brain begins to occur years prior to the clinical onset of Alzheimer’s disease (AD). Prior to Aβ aggregation, levels of extracellular, soluble interstitial fluid (ISF) Aβ, which are regulated by neuronal activity and the sleep-wake cycle, correlate with the amoun...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3654377/ https://ncbi.nlm.nih.gov/pubmed/22956200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004291 |
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