Amyloid-β Dynamics are Regulated by Orexin and the Sleep-Wake Cycle

Amyloid-β (Aβ) accumulation in the brain extracellular space is a hallmark of Alzheimer’s disease (AD). The factors regulating this process are only partly understood. Aβ aggregation is a concentration-dependent process that is likely to be dependent on changes in brain interstitial fluid (ISF) leve...

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Main Authors: Kang, Jae-Eun, Lim, Miranda M., Bateman, Randall J., Lee, James J., Smyth, Liam P., Cirrito, John R., Fujiki, Nobuhiro, Nishino, Seiji, Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789838/
https://ncbi.nlm.nih.gov/pubmed/19779148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1180962
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