The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β

CBA mice infected with the helminthSchistosomamansonidevelop severe CD4 T cell-mediated hepaticgranulomatous inflammation against parasite eggs associated with a robust Th17 cell response.We investigated the requisites for Th17 cell development using novel CD4 T cells expressing a transgenic (Tg) TC...

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Detalhes bibliográficos
Main Authors: Shainheit, Mara G., Lasocki, Krzysztof W., Finger, Eduardo, Larkin, Bridget M., Smith, Patrick M., Sharpe, Arlene H., Dinarello, Charles A., Rutitzky, Laura I., Stadecker, Miguel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653625/
https://ncbi.nlm.nih.gov/pubmed/22003203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101445
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