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MeCP2 binds to 5hmc enriched within active genes and accessible chromatin in the nervous system

The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests that mechanisms interpreting 5hmC in the central nervous system (CNS) may differ from those present in embryonic stem cells. Here we present quantitative, genome-wide analysis of 5hmC, 5-methylcytosine (5mC) and ge...

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Hlavní autoři: Mellen, Marian, Ayata, Pinar, Dewell, Scott, Kriaucionis, Skirmantas, Heintz, Nathaniel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653293/
https://ncbi.nlm.nih.gov/pubmed/23260135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.022
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