WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation

WNT signaling controls many biological processes including cell differentiation in metazoans. However, how WNT reprograms cell identity is not well understood. We have investigated the potential role of cellular metabolism in WNT-induced osteoblast differentiation. WNT3A induces aerobic glycolysis k...

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Bibliographic Details
Main Authors: Esen, Emel, Chen, Jianquan, Karner, Courtney M., Okunade, Adewole L., Patterson, Bruce W., Long, Fanxin
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653292/
https://ncbi.nlm.nih.gov/pubmed/23623748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.03.017
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