Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria

Traditional proteomics provides static assessment of protein content, but not synthetic rates. Recently, proteome dynamics with heavy water ((2)H(2)O) was introduced, where (2)H labels amino acids that are incorporated into proteins, and the synthesis rate of individual proteins is calculated using...

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Detalhes bibliográficos
Main Authors: Kasumov, Takhar, Dabkowski, Erinne R., Shekar, Kadambari Chandra, Li, Ling, Ribeiro, Rogerio F., Walsh, Kenneth, Previs, Stephen F., Sadygov, Rovshan G., Willard, Belinda, Stanley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652088/
https://ncbi.nlm.nih.gov/pubmed/23457012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00933.2012
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