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Cardiac Mitochondrial Proteome Dynamics with Heavy Water Reveals Stable Rate of Mitochondrial Protein Synthesis in Heart Failure Despite Decline in Mitochondrial Oxidative Capacity

We recently developed a method to measure mitochondrial proteome dynamics with heavy water ((2)H(2)O)-based metabolic labeling and high resolution mass spectrometry. We reported the half-lives and synthesis rates of several proteins in the two cardiac mitochondrial subpopulations, subsarcolemmal and...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Shekar, Kadambari Chandra, Li, Ling, Dabkowski, Erinne R., Xu, Wenhong, Ribeiro, Rogerio Faustino, Hecker, Peter A., Recchia, Fabio A., Sadygov, Rovshan G., Willard, Belinda, Kasumov, Takhar, Stanley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363075/
https://ncbi.nlm.nih.gov/pubmed/24995939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.06.014
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